Thanks for that link, I didn't knew about the opiate receptors resensitization.
I suspected, from personal experience with various NMDA antagonist that it's blockade has a similar effect on the dopamine¹ and nicotine/acetylcholine² families of receptors (but not on GABA³ nor CB⁴).
1- A few days after a dose of whatever the NMDA antagonist I currently had my ADD drug felt magical like the first month I took them.
2- As a teen I use to smoke... But I never smoked a cigarette again after trying to smoke during a DXM ( like ketamine, it's a substance with a really funky pharmacological profile ) trip. Every puff felt like it was my first puff but worse.
3- I take 1.5mg of clonazepam a night since I was 18 (I am over 40 now) and they had no effect whatsoever on my sensitivity nor my dependance. Clonazepam dependance is insidiously strong... it was prescribed for anxiety and insomnia, I never abused it, yet I cannot stop, each time I tried my attempt ended a few days later as I started to see scary bugs on the wall.
4- I used to be a pothead and while the combo is quite enjoyable they did nothing on my tolerance to cannabis.
p.s. Nowadays I read about drugs and I have as much fun as I did when I did use them... so I understand your enthusiasm, neuropsychopharmacology is fascinating.
I suspected, from personal experience with various NMDA antagonist that it's blockade has a similar effect on the dopamine¹ and nicotine/acetylcholine² families of receptors (but not on GABA³ nor CB⁴).
1- A few days after a dose of whatever the NMDA antagonist I currently had my ADD drug felt magical like the first month I took them.
2- As a teen I use to smoke... But I never smoked a cigarette again after trying to smoke during a DXM ( like ketamine, it's a substance with a really funky pharmacological profile ) trip. Every puff felt like it was my first puff but worse.
3- I take 1.5mg of clonazepam a night since I was 18 (I am over 40 now) and they had no effect whatsoever on my sensitivity nor my dependance. Clonazepam dependance is insidiously strong... it was prescribed for anxiety and insomnia, I never abused it, yet I cannot stop, each time I tried my attempt ended a few days later as I started to see scary bugs on the wall.
4- I used to be a pothead and while the combo is quite enjoyable they did nothing on my tolerance to cannabis.
p.s. Nowadays I read about drugs and I have as much fun as I did when I did use them... so I understand your enthusiasm, neuropsychopharmacology is fascinating.
p.p.s. If you didn't read this book https://archive.org/details/stahlsessentialp00stah I strongly recommend it !