In my experience, the biggest issue with not using mypy, is the number of mypy plugins you lose access to. It's not uncommon for projects (or their ecosystems) that rely heavily on metaprogramming to provide mypy plugins to shore up the gaps in the type system; e.g. Django, strawberry, pydantic.

But other than that, I generally prefer pyright day-to-day because the experience using VSCode is far better.