Yes, but you still need a module like typedload to do the runtime checking.
TypedDict performs no checking by itself at runtime.
class A(TypedDict):
a: int
A(d=32)
# Returns {'d': 32}
typedload.load({'d': 32}, A)
# TypedloadValueError: Value does not contain fields: {'a'} which are necessary for type A
After the load, you can trust that your objects are well formed and let mypy do its thing.
So types can be useful at runtime as well. Otherwise the alternative would be to use raw dictionary, which mypy can't check.
pydantic does a similar thing but it uses its own different typing, so it needs a mypy plugin or it flags everything as wrong.