I’ve been using a 43” display for 2-3 years, and a 2x2 quad setup before that. The single 43” display is better for ergonomics than the quad setup and I haven’t had an issue. Most of what I actively work on is at eye level, while the stuff up high are mostly things I just need to quickly glance at or use for 20 seconds here and there. If I need to interact with it more, I just drag it down to the middle of the screen. I don’t even think about it really.