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Misunderstanding here. The question is at what age is the base rate in the population sufficiently high that a test with a certain sensitivity and specificity useful net risks. Multiple studies have shown that these screening programmes don’t have a huge impact on mortality - excluding lead time bias etc. and noting the c. 10 in 100k extra cases of cancer caused by the screening. Here’s a review for prostate screening that’s even more damning about its usefulness - https://med-fom-urlgsci.sites.olt.ubc.ca/files/2007/06/P-ca-...


would it be possible to use MRI for screening?


MRI scans take longer, are often more uncomfortable for the patient (being in an enclosed, noisy machine), require much larger capital investment than an X-ray (and therefore supply is more limited), and have a higher cost per exam than an X-ray.

It almost certainly would be possible to use MRI for screening, but the impact would be a reduction in availability and a higher cost.




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