Unpopular opinion here, I'm sure, but this line of thinking is precisely what kneecapped Star Wars: the need to know everything. World-building is the antithesis of character-building.

We fall in love with this stories because of the characters. We then become fascinated with the possibility of the worlds, then the worlds are built out, and then it sucks, and then people go "well, no, the world should have been built this way or that way," and then that's tried, and it sucks too, and now the franchise has lost all that made it interesting in the first place and all sci-fi just kind of devolves into one bland soup of all the other sci-fi, and everyone along the way forgets to write compelling characters.

And who are the compelling characters in Blade Runner? Those who were written about: Replicants, and those who hunt them. The world was not the point, the characters and their conflict/struggles and the issues those raise were the point.

Why do we need to know about the other big evil corporations, when the sense that there's only one, and that's the one that builds the Replicants, is so much more compelling? Not to mention that the primary function of the Tyrell/Wallace Corporation is to serve the characters.

Who cares how space travel works as long as it does? Who cares what the colonies produce, unless the fruits of that production can aid in telling an interesting story revolving around a character as interesting as Roy Batty? Can you really tell a compelling story about a worker on an off-world colony -- and if the answer is "yes," why does it need to be part of Blade Runner, and not its own thing? The colonies are almost certainly not interesting because they're better than Earth -- there's likely less conflict.

Hollywood folks are incredibly influenced by precisely this kind of discourse on the internet (source: I work in Hollywood), and it drives me nuts because it's just the blind leading the blind.

Going "what else could happen in this world" feels good, but it almost always is the death knell of a franchise, because it's fundamentally the wrong question to ask when writing fiction. The question that results in good story-telling is "who is this person," or "who does this happen to," and allow the world-building to grow organically from there.

I hope 2099 explorers the stories of people/replicants away from earth. No need to bring back to old characters (although I guess they could bring back certain replicant models).

Not directly related (some) but the setting of Alien/Aliens is awesome. A deep space ship just out there on its own, great vibe.

then you would really enjoy "the expanse" - esp. the latter seasons.