I wonder why a pig heart rather than one from another primate? The article mentions a baboon heart in an earlier attempt at xenotransplantation with an infant. Is a pig’s heart as, or more, compatible or is it more a matter of availability?
At age 2, I was a candidate for a monkey heart transplant, as I had a perforated aortic valve and surgery on tissue with the consistency of wet-toilet paper in an infant had a very high mortality rate (the girl on the table before I went in had died). My parents declined the monkey transplant. Good thing. The intended recipients of multiple attempts at the monkey hearts, died. I eventually received a primitive mechanical implant, which I quickly outgrew. By the 80s I had another surgery to replace it (https://en.wikipedia.org/wiki/Bj%C3%B6rk%E2%80%93Shiley_valv...). This had it's own dangers, as the strut would fail along 2 ends of a sizing graph (most people were at the larger size end). I sat safely on the bell curve. I kept that into my 30s which caused various problems with the aortic stem and thickening of the left ventricle.
Now I'm rocking the On-X, which is superior in innumerable ways.
Pigs are very anatomically similar to humans but due to being a food source there were probably also fewer ethical concerns compared to using primates.
It's really quite fascinating -- they aren't particularly close to us genetically, but because they're a similar sized mammal with an omnivore diet, you can teach their macro-biology from the same textbook.
Yep, back in high school we had a few days devoted to dissecting and documenting the anatomy of a fetal pig. It was really surprising how similar they actually were.
Because they're suitable enough (size, pump performance, etc) and also mass produce-able. The rest is for the same reason we don't eat Monkey bacon via mass farming of monkeys.
IANAD, but from what I remember back when trans-species heart transplant research started in the 80's, it was that pig heart tissue is most similar to human heart tissue.
Hopefully there is a D on HN who can explain better.