if possible, leave enough clearance to swap a vertical for a horizontal in the 11th hour ;) or use larger/more common widths like 8 or 16 position connectors even if you only need 5 or 11 or them filled

if you can reach for creative solutions, a couple months ago it was cheaper for me to use one of those 6-pin power only USB-C connectors with an off-the-shelf USB-C cable than a 6-pin molex cable assembly...