As it happens, I have a USB stick with Fedora 34 on it. I tried it a few months back after Ubuntu and POP OS and found it to be great with one issue: Nvidia graphics! Too much fannying about to get them to work.
If i just used the built-in Intel graphics it was perfect. Every app worked (I'm a .NET dev), everything was fast and stable... it was great.
The issue with the graphics was to do with having an HDMI and DP connection at the same time and caused a crash in 46x version of drivers. 47x wasn't out at the time but it is now... perhaps it's time!
No problems whatsoever with Ubuntu based distros (like Mint) with Nvidia whatsoever. If you want to install the newest Mesa from a PPA, one of them has instructions for Mint. I'd recommend openSUSE over Fedora, less Gnome focused, more pragmatic than laboratory to push the boundaries and rolling release in case of Tumbleweed. Instructions for Nvidia drivers are here [0]. Just saw a guide to Setting up MicroOS as a desktop OS (their equivalent to Fedora Silverblue, immutable OS). Might try that one on the machine i still have to migrate from a Cinnamon/KDE-FrankenMint to Tumbleweed.
If i just used the built-in Intel graphics it was perfect. Every app worked (I'm a .NET dev), everything was fast and stable... it was great.
The issue with the graphics was to do with having an HDMI and DP connection at the same time and caused a crash in 46x version of drivers. 47x wasn't out at the time but it is now... perhaps it's time!