Yes. You will likely need to be running a signed Steam install plus a signed version of the game. I’m 100% confident that it will be figured out in a repo like the aur, but it may be some work for Ubuntu folks and whatnot.
Archlinux steam user here: Steam auto-updates and Steam's default Proton install is pulled down by Steam and stored within it's paths.
Mostly this would affect anything that needs an unsupported build of Proton to work properly. Which is mostly lots of games that use the insane plethora of media presentation layers every big company has added to Windows over the decades.
From what I've seen of games on Twitch, EAC style games tend to not rely on FMV and are generally 'all live' so there shouldn't be many problems.
