>I'm not sure what if any negative selection system is used to prevent accidentally targeting autoantigens in addition the foreign antigen
From an evolution perspective, it may improve survival chances to form antibodies with partial autoimmune match and beat the infection, rather than form less antibodies period. Also because the infection is an immediate death threat, while autoimmune disorders (like Celiac's) can be a major inconvenience that doesn't stop reproduction.
From an evolution perspective, it may improve survival chances to form antibodies with partial autoimmune match and beat the infection, rather than form less antibodies period. Also because the infection is an immediate death threat, while autoimmune disorders (like Celiac's) can be a major inconvenience that doesn't stop reproduction.