I guess the installation via pip is only best effort in the sense that they can't support every platform that pip is able to run on. For example their dependency on the "cryptography" library might cause problems on platforms which can't get a pre-compiled version from PyPi and have to built it from source.
If you are on x86 and use a distribution with glibc I wouldn't expect any problems.
I've had no issues installing it from debian apt repos on arm64 and amd64... I mean, if you don't want to use certbot and prefer something else, fine, but I can't see how docker/pip/snaps are the only options.
If you are on x86 and use a distribution with glibc I wouldn't expect any problems.