Recommendation from me as well. Have been using this script for multiple years now without a single issue. The minimal code is awesome for avoiding unnecessary external dependencies and complexity.
From the gh page doc it requires too much stuff to set up. Imagine if you need certs for >10 domains I prefer lego + cronjob or caddy. Most web apps speak http now and it's just a matter of proxying to a local port, unless you are using php, uwsgi, psgi. Php-fpm is also well supported.
https://github.com/Tronde/acme-tiny
It's an acme client in a single, small, stand-alone Python file.
I reverse-engineered it and ported it to Common Lisp. I haven't published the result, but I'd be happy to do so if anyone is interested.