We've had a lot. Asbestos, leaded paint, PCBs, Dioxins, plasticizers (not just BPA, bunch of others.) Too many pesticides to count.

Fracking chemicals are horrific and completely unregulated.

Indoors you've got VOCs like formaldehyde leaking out of furniture and carpets. There's also the fireproofing chemicals in furniture that are seriously nasty stuff. "New car smell" is also chock full of gasses that aren't good for you.

Near waterways we're doing a fantastic job of killing off everything via nitrogen runoff from lawns, farms, and septic systems.

Bush and Trump both raised limits for stuff like arseni in drinking water. PFOA and PFOS contamination is showing up all over the place thanks to airports and firefighter training facilities using them and letting it just run off: https://www.epa.gov/ground-water-and-drinking-water/drinking...

A radio program recently covered how the EPA was pressuring its researchers to strip out mention of possible analogues if those analogs were known toxins. What little review the EPA does is nearly useless because the industry has inserted itself so well.