Thank you for sharing the link. I do note that this is an observational study of 255 people. It contradicts a randomized trial with 1,561 people in the HCQ-arm alone vs 3,155 receiving usual care (RECOVERY).

When they are studied as a prophylactic or at early stage, they really prove out. I think that trial you referenced was in late stage severe cases, almost feels like they gamed that design to fail.

The study you have cited was entirely confined to 255 patients, all of whom required mechanical ventilation, 70% of whom died by day 90. That's severe COVID, not "prophylaxis."

Yeah I know, and I didn't expect that. It's even better the earlier it's applied though.