I think many (most?) Guix System users are desktop users. Having transactional upgrades and rollbacks, downgrade prevention, and secure updates is great whether you're a desktop user, a developer, or a server admin.

To tweak packages, Guix has "transformation options" that make a number of tweaks readily accessible from the command line: https://guix.gnu.org/manual/en/html_node/Package-Transformat...