I'm not somebody well informed about neuroscience hence apologies if I'm implying something that's against the common knowledge in your domain. One impression upon reading articles like these seems to be that there's a lot of research and curiosity about the way brain works together but the core model of "brain is composed of communicating neurons" seems to be generally accepted. Does that suggest that we already understand how a single neuron behaves in isolation? I'm mainly interested in the microscale model from the perspective of simulation, for example in the Wiki page of the Human Brain Project (https://en.wikipedia.org/wiki/Human_Brain_Project) among the obstacles it's mentioned that "detailed neuron representations are very computationally expensive", does it mean that we already cracked the microscale, i.e., defined exactly how a neuron behaves in a computational (mathematical) model? Perhaps the substantial intricacies of the brain can also arise in the microscale level depending on cellular mechanisms, nutrition and other side effects?