Yeah, but they cause cancer. Things like lymphomas that killed Bob Ross cuz those are the pigments painters use.

Ross's lymphoma was thought to have been caused by dichloromethane exposure from his odorless paint thinner (and him 'beating the devil' out of his brushes aerosolizing it).

It's now banned in paint thinners as a result of some pretty long lobbying efforts. It's a little sad, since chemicals like DCM are hard to replace, but if it saves the lives of our artists at the expense of them having a bit of a harder time cleaning their brushes, maybe we can live with that.

Yes, just another few elements to leak into environment, rivers, oceans.

It does not matter if the chemical compound is inert or not, the elements will be well incorporated into a new vector of nature.