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Remember that the threshold shouldn't be "fully safe", the threshold should be "better than the alternatives". If the alternative is COVID, that's a pretty low bar to clear. Given that we may have several vaccines to choose from it's worth a bit of effort to weed out any unsafe ones, but remember that every day of delay may cost thousands of lives.


> If the alternative is COVID, that's a pretty low bar to clear.

It's really not a low bar. A healthy 35-year-old has maybe 0.01% chance of dying, 1% chance of lasting side-effects from Covid. Untested medicines can be way more dangerous than that: thalidomide, for example, has a 50%+ chance of causing stillbirth or birth defects for pregnant women [0].

If you just vaccinate the old and sick, risky vaccines start to look more attractive. But those people also have a greater risk of side effects and are underrepresented in the clinical trials, and most vaccination strategies mooted so far for Covid are based on mass vaccination of healthy people. So it has to be really safe for that to work.

[0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737249/


> 1% chance of lasting side-effects from Covid.

Source?

But even if it were "only" 1%, that is still a pretty easy bar to clear for vaccines.


So may every day of rushing. These testing/approval protocols aren't designed simply to provide job security. They were much cheaper and quicker before events like this one: https://en.wikipedia.org/wiki/Thalidomide_scandal


I do remember.

The anti-vax nuts make discussion vaccination risks difficult because everyone pushes back to different direction just to be on the safe side.

Existing vaccine testing and approval process have more or less the the right balance. Sometimes vaccines are withdrawn, in general they are safe.


15000 also becomes a much smaller number as you start to consider factors which may change how someone reacts to the vaccine (gender, race, age, preexisting conditions, etc)


You know these trials explicitly select for diversity in all those aspects right?


I don't know




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