iOS 14 has improved controller support so I think it will translate to Mac as well when you play the game there. Fortnite switches automatically to controller mode when you connect one to your iOS device through bluetooth.

Fortnite: https://www.youtube.com/watch?v=0KsQ27Ddtyw

https://developer.apple.com/news/?id=hk2u622s

https://developer.apple.com/videos/play/wwdc2020/10614/

Also I used the PS4 Remote Play with the Dualshock controller on Mac and it worked perfectly

https://remoteplay.dl.playstation.net/remoteplay/lang/en/ps4...