This study wasn't just about psilocybin. The patients received 11 hours of professional therapy. The psilocybin was used as an adjunct.
The theory is that psilocybin increases suggestibility and openness to new ideas, making the therapy easier to integrate.
Note that increasing suggestibility isn't a universally positive trait, especially for people doing ad-hoc dosing alone without therapy. In fact, it's uncommon to hear "bad trip" stories where people end up in prolonged depressive or anxious episodes following a trip.
There is no evidence here that taking psychedelics without therapy is positive for patients, so it's extremely unlikely that dosing someone who is sedated or in a coma would have any effect.
The theory is that psilocybin increases suggestibility and openness to new ideas, making the therapy easier to integrate.
Note that increasing suggestibility isn't a universally positive trait, especially for people doing ad-hoc dosing alone without therapy. In fact, it's uncommon to hear "bad trip" stories where people end up in prolonged depressive or anxious episodes following a trip.
There is no evidence here that taking psychedelics without therapy is positive for patients, so it's extremely unlikely that dosing someone who is sedated or in a coma would have any effect.