Considering there's no evidence it's toxic and you can do it every month because that's how long it takes for your tolerance to wear off, 3 months is a lot of time.
Consider normal SSRIs where you feel like crap for a month, try N more (which could mean many more months) until you find one that suits you, then have side-effects, then try to get off them so that's another couple of months of misery.
That's countless doses, money, time spent in misery vs one day of mushrooms every 3 months.
Normal psych meds are to be avoided at all costs and only be used if absolutely necessary, after you have tried everything else; atleast in my opinion.
I think the primary reason for “normal” psych meds is they’ve been tested well for harm reduction first and foremost. That’s why the front line SSRIs are front line, they have less chance of a negative effect. Downside is it’s mild, and there’s plenty of evidence that the “low seratonin” theory of depression doesn’t apply to many.
Psilocybin is an intense acute experience. People can have negative effects. I hope we do studies to find how to use it most safely, or isolate the beneficial aspect without the intoxicating effects.
The research and anecdotal reports coming out about microdosing is pretty exciting for the field of depression treatment.
Though some take greater dosages, many people are finding relief from sub-perceptual doses: indicating that the typical hallucinations and disorientation associated with recreational psilocybe use is likely not necessary for achieving anti-depressive effect.
I've also read of some interesting work being done creating "anti-abuse" formulations, where the active ingredients are compounded with Niacin or other drugs that cause unpleasant physical side effects at high doses to discourage overdose/abuse/recreational use. "Stamet's stack" seems to be the most common of these.
Definitely needs much more research into these compounds, but seems a very promising frontier for antidepressant pharmacology.
> I've also read of some interesting work being done creating "anti-abuse" formulations, where the active ingredients are compounded with Niacin or other drugs that cause unpleasant physical side effects at high doses to discourage overdose/abuse/recreational use.
Of course they can’t just let us use the natural substance that has existed for most, of not all, of human history.
Consider normal SSRIs where you feel like crap for a month, try N more (which could mean many more months) until you find one that suits you, then have side-effects, then try to get off them so that's another couple of months of misery.
That's countless doses, money, time spent in misery vs one day of mushrooms every 3 months.
Normal psych meds are to be avoided at all costs and only be used if absolutely necessary, after you have tried everything else; atleast in my opinion.