Indeed. I use the Dvorak layout (a choice I made twenty years ago and have stuck with since my typing speed did improve, by virtue of finally learning to touch type properly), and many shortcuts make no sense. On the other hand, I actually found emacs much more comfortable to use.
The P and V operations on semaphores are from Dutch. I find this difficult, "The V kind of looks like a down arrow.. but wait no that's increment. The P could mean plus.. wait no that's decrement..."
And shortcuts based on finger distance must suck for anyone using a non-qwerty keyboard (especially a non-latin character based language!).