There is a tool called "Click Monitor DDC" that can control a lot of display settings via DDC. It warns that changing settings too often would wear out a display's flash memory used for storing the settings. This shouldn't be limited to changing settings via DDC but automated setting changes might occur lots of times more often than manual changes.
How is changing the setting from DDC different from changing it manually through the monitor's buttons? I think the warning is there for programmatic usage to warn people against changing the settings in a while loop or similar, but changing at a reasonable rate shouldn't be a problem.
