I think a key part is also the dose in which you get infected that leads to illness. When you're in the open air, breathing and chanting, the dose of the virus is so low, that the immune system can easily defend against it.
Also, the virus doesn't kill most people, the human immune (over)reaction does.
This is my laymen's way of describing a (deadly) course of the virus and disease.
1.1. person breaths in microparticles (aerosols) contaminated with the virus
1.2. breaths in low or high dose (in further steps shown as L and H)
1.3. (L and H) directly deep into the lungs [1] (almost like intracellular viral infection)
2.1. (L and H) innate arm of immune system tries to combat it
2.2. (L and H) adaptive arm of immune system is being activated [2] (takes at most 7 days to mount a significant response)
2.3. (L) virus replicates slowly and is kept in check, because low dose is easier to combat by innate arm of immune system (availability of Vitamine D seems key as it exhibits direct antiviral activities [3] probably Zinc as well as it inhibits RNA replication of the virus [4])
2.4. (H) virus replicates fast because the high dose can't be handled by the innate arm
-> This is the point when most people will either get more ill and be hospitalized, or recover. This is also when it's too late for HCQ and Zinc to be effective. (Set of studies showing effectiveness for early or late treatment with HCQ + Zinc + Azithromycin[5])
3.1. (L) virus is controlled and the innate arm of the immune system can handle the virus. The adaptive arm cleans up the last bits of the virus and person is no longer ill.
-> Low dose infected person might stay Asymptomatic or experience a Light Cold or minor fever.
3.2. (H) virus is out of control and the adaptive arm reacts with an overreaction of the antibodies resulting in a cytokine storm
3.3. Person gets severe inflammation and thrombosis and gets heavily ill.
-> High dose infection: this is the point of no return and anyone who reaches this is bound to have a long track of recovery in front of them, or death.
I've added some sources, be aware that for each source there's multitude of other sources claiming the same thing. Research yourself!
It does include everything. It's the narrative that comes from the few negative results, as well as the big Lancet article that was retracted that got the news very negative.
But if you know of missing studies please add them.
The disagreement of effectiveness is mostly about it being used in a late stage of the disease (as mentioned), not in early stage.
Also, the virus doesn't kill most people, the human immune (over)reaction does. This is my laymen's way of describing a (deadly) course of the virus and disease.
1.1. person breaths in microparticles (aerosols) contaminated with the virus 1.2. breaths in low or high dose (in further steps shown as L and H) 1.3. (L and H) directly deep into the lungs [1] (almost like intracellular viral infection)
2.1. (L and H) innate arm of immune system tries to combat it 2.2. (L and H) adaptive arm of immune system is being activated [2] (takes at most 7 days to mount a significant response) 2.3. (L) virus replicates slowly and is kept in check, because low dose is easier to combat by innate arm of immune system (availability of Vitamine D seems key as it exhibits direct antiviral activities [3] probably Zinc as well as it inhibits RNA replication of the virus [4]) 2.4. (H) virus replicates fast because the high dose can't be handled by the innate arm -> This is the point when most people will either get more ill and be hospitalized, or recover. This is also when it's too late for HCQ and Zinc to be effective. (Set of studies showing effectiveness for early or late treatment with HCQ + Zinc + Azithromycin[5]) 3.1. (L) virus is controlled and the innate arm of the immune system can handle the virus. The adaptive arm cleans up the last bits of the virus and person is no longer ill. -> Low dose infected person might stay Asymptomatic or experience a Light Cold or minor fever. 3.2. (H) virus is out of control and the adaptive arm reacts with an overreaction of the antibodies resulting in a cytokine storm 3.3. Person gets severe inflammation and thrombosis and gets heavily ill. -> High dose infection: this is the point of no return and anyone who reaches this is bound to have a long track of recovery in front of them, or death.
I've added some sources, be aware that for each source there's multitude of other sources claiming the same thing. Research yourself!
[1]: https://www.intechopen.com/books/rhinosinusitis/aerosol-part... [2]: https://en.wikipedia.org/wiki/Adaptive_immune_system#Functio... [3]: https://youtu.be/Mdc7T2UTHBI?t=216 [4]: https://youtu.be/WZq-K1wpur8?t=447 [5]: https://c19study.com/