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It's been a while since I've done biology, but if the boy was ingesting estrogen in a pill form, doesn't that also put additional strain on the liver?


A little, but not always enough to be a problem. I took 4x the does he was on for a year without any change in liver function markers. Some transfem people take 1-4x his does for life.


Testosterone carries a significant risk of liver damage — even if it's injected. Estrogen doesn't, ingested or otherwise.


That's interesting. Why the difference?


I'm not sure if science knows why yet. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897047/ may be a good starting point, but IANAYD etc.




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