"On a biological level, our eyes prefer the contrast between a light background and dark foreground."
On a biological level, our eyes prefer not to stare at a light source all day every day. Yet here we are.
For monitors, you should be adjusting the brightness frequently and in accordance with the ambient light level.
If you do that, you should perceive the background of your light mode content as neutral and so inoffensive that you don't even notice it.
"On a biological level, our eyes prefer the contrast between a light background and dark foreground."
On a biological level, our eyes prefer not to stare at a light source all day every day. Yet here we are.