For line drawing, tablets seemed weird for my brain. I'd rotate the tablet to draw comfortably, but a straight line is different because my monitor didn't rotate. But if you look online, people clearly get used to things like this with enough practice.

Cintiqs, iPads, and other tablets don't require this adaptation, though. I've also been kind of amazed how well people can write using mice when forced to (from watching MOOC classes).