There is a famous book by Arno Schmidt, ZETTEL'S TRAUM (sic!) with only 2000 copies published because it has such a complicated layout. The gargantuan novel was published in folio format with 1,334 pages. The story is told mostly in three shifting columns, presenting the text in the form of notes, collages, and typewritten pages.

https://de.wikipedia.org/wiki/Zettel’s_Traum