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> it would be very hard to ethically approve a randomised trial of teeth brushing over a long period.

The ethics aren't too difficult because we don't have strong evidence one way or the other. I think a bigger issue would be blinding the study participants. The groups assigned to the higher frequency brushing may change other routines (e.g. diet).

> The problem is that the profit margins on carbonated flavored water

It could also be the strong acidity of a lot of drinks in general, even if we replace the carbonation/sugar with something else.



Importantly, phosphoric acid is the worst, carbonic acid is not as strong. I'm recently switching from sugared colas with phosphoric acid to naturally flavored carbonated water




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