This depends on your VPN service provider, not the WireGuard software - the software itself simply tunnels your traffic to the VPN provider, who then route it out to the internet. It doesn't matter if you use IPsec, OpenVPN, PPP, L2TP or WireGuard to send your traffic to your provider if their address has been blacklisted.
What WireGuard does get you is a much simpler configuration format for VPNs (IPsec is notoriously overcomplicated) and a modern set of cryptography choices (most other VPN techologies are old and come with legacy baggage, or strange TLS-like connection setup that then becomes its own thing like OpenVPN).
Pretty much any VPN be used to change your location. However, it depends where the server lives, what IP you get from that, and whether or not it's on a blacklist by netflix.
Wireguard is the protocol/tech, not a VPN Service Provider.
