Have a friend who had a habit of picking up furniture etc from the side of the road, and (perhaps related) got bedbugs. I am very very hesitant to do the same.
Definitely, but I would use a similar amount of caution with used luggage. Luggage is used for visiting many places, left in hotel rooms and overhead bins (high traffic areas), hold clothes, lots of seams and nooks and crannies ... pretty ideal bedbug territory.