"Enterprise development" is not the same as "serious development". Anyone still doing regular old JavaScript without the transpiling and megaframework dependencies is arguably taking their task more seriously than those who are.
I'm sorry, but after having used TypeScript there's no way I'm ever going to back to writing pure JavaScript anymore (for anything but the most trivial stuff). It's borderline irresponsible, IMO.
I'd like to say I love typescript, too. It's better for collaborative development than raw JS. My point is different, that working in the "low level" or raw JS, obfuscated or not, is where the substantive work happens. Good example is the people working on frameworks.
Who's talking about transpiling and mega-frameworks? I'm simply talking about the headache of managing dependencies on a reasonably complex project. The "mega-frameworks", by which I assume you mean products such as Angular, React, Vue, etc., are often not the worst offenders when it comes to external dependencies. Of course, when you start pulling in extensions that story can change, but that can be true of pulling in any other library that provides equivalent functionality (where such exists).
