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Thank you for the long answer!

Yeah, few biological processes care about the effect of pressure other than the changes caused in solubilities etc. The physics of the sparging process is very interesting. Do you also do countercurrent (downwards) flow of the water in the sparging unit? (Settling velocities of microdroplets is a subject close to my heart.) I guess anti-foaming is also a big concern there.

A word of caution on pressure classes: in some conservative industries (e.g. oil and gas) they won't let you get away with using piping components rated at some pressure class as pressure vessels at the same pressure class without additional certification. Say, if you were using a piece of large diameter 150 lb rated pipe with flanges at each end as your reactor body. Certification as a pressure vessel is more exhaustive/expensive than certification for piping components.

Nice trick going with the PSA unit instead of accepting the large O2 partial pressure penalty. It sounds like you guys run a tight ship, all the best of luck!




Thanks so much for this advice, very helpful!




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