Do you know Jack Ma? His current net worth is 28.8 billion USD. Before he became successful he applied at 30 jobs when he was looking for work and was rejected from all of them, including a job at KFC where 24 people applied and they hired everyone but him. He wrote to Harvard for a total of 10 times and was knocked back every single time.
It's probably the right balance of nature & nurture that comes into play. The only thing to note is that both those learnings happen subconsciously but the real masters seem to be making the right decisions consciously which leads me to think that they tend to have overwhelming self discipline & self awareness.
Goals + perseverance + time = your magic formula.