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Fascinating

There appears to be a lot of confusion in the comments around what the MCP is and how it is different API.

I've done a deep dive here before.

Hope this clears it up: https://glama.ai/blog/2025-06-06-mcp-vs-api


That "deep dive" is an apples-to-oranges comparison. MCP is also a "HTTP API" that you so criticize.

You also somehow consistently think LLM making tool calls against an OpenAPI spec would result in hallucination, while tool calls are somehow magically exempt from such.

All of this writing sounds like you picked a conclusion and then tried to justify it.

There's no reason an "Agentic OpenAPI" marked as such in a header wouldn't be just as good as MCP and it would save a ton of engineering effort.


Thanks.

The video link seems to be missing in the section: Bonus: MCP vs API video


Yes, the exact same conclusion I arrived to.

I did find writing about it therapeutical though.

The goal is to move past the thought lingering at the back of my head.


OpenRouter, Glama ( https://glama.ai/gateway/models/claude-sonnet-4-5-20250929 ), AWS Bedrock, all of them provide you access to all of the AI models via OpenAI compatible API.


so this gives a good reason between valkey and redis, but what about dragonfly? some benchmarks show crazy advantage over Redis (and I assume valkey too)


switched to Dragonfly and can confirm that the throughput makes a noticeable difference to the user experience


Use one of the router services


Serious question: With all the advancements in mice medicine, are we theoretically able to create immortal mice?


The robust mouse rejuvenation study is ongoing. Basically they took a lot of mice and threw the kitchen sink of promising age reversing therapies at them: https://www.levf.org/projects/robust-mouse-rejuvenation-stud...

Just off the top of my head, I think the longest they ever got a mouse to live in a study was the C-60 study where they wanted to test whether it was toxic and the mouse lived almost twice their normal lifespan. This paper has been cited over 300 times, so it's not like people haven't taken notice of it. There are a few supplement companies selling c-60 olive oil too:

https://www.sciencedirect.com/science/article/abs/pii/S01429... "Here we show that oral administration of C60 dissolved in olive oil (0.8 mg/ml) at reiterated doses (1.7 mg/kg of body weight) to rats not only does not entail chronic toxicity but it almost doubles their lifespan"


Bearing in mind that the C60 study (from 2012) has never been succesfully replicated since, despite multiple attempts.


Did we manage to accidentally make something live twice as long and then abandon efforts to replicate the results?


Or were there other problems in the data?


No. Originally we sketched out 9 hallmarks of aging, and it has since increased to twelve. We don’t have a full picture of immortality yet, let alone conquering it.


Even if we can't do it biologically i wonder how much we could extend it with artificial organs?

Most deaths seem to be cardiovascular, heart disease, stroke, then followed by cancer.


If we count a permanently inflamed organic blob in roughly the shape of a mouse covered by surgical scars constantly pumped with anti-rejection drugs and hooked up to a blood filter we could probably make the mouse immortal now. It might not enjoy living though.


Funnily enough, chronic inflammation (inflammaging) is also a hallmark of aging.


I mean, that’s a good start honestly. Makes me optimistic about the QoL the mouse might be able to have in 50 years.


Given that you die, when one vital organ dies it will eventaully hapen in this way or another. I read somwhere and that stuck in my brain, that maxmimal logevity for humans is estimated to be approximetly 125 years.


>> I read somwhere and that stuck in my brain, that maxmimal logevity for humans is estimated to be approximetly 125 years.

Oh, that's just derived from old theology.

Genesis 6:3, 'Then the LORD said, “My Spirit will not contend with humans forever, for they are mortal; their days will be a hundred and twenty years.”'

This kinda got spread throughout the zeitgeist long ago as a "maximal lifespan", but the reality is that only 3 in 10,000 even make it to 100. There's no hard cutoff, but functionally essentially no one gets to 110.

Scientifically, there's no hard reason we couldn't increase our lifespans indefinitely, but we've got a lot of work to do before we'll be able to get a reasonable number of people up to 125.


That doesn’t sound like you’re disagreeing with gp.


Probably quite a bit, but some of the hallmarks (decreased intercellular signaling, reduced ATP activity, decreased macroautophagy) seem so systemic I’m not sure we’re even close.


I think if we were, we would have immortal mice.


Having lived in some of the apartments I've lived in, I'm not sure that we don't.


Are you sure the mice don't change?


One older balding mouse would hold court in the pantry periodically-- he had a little gold ring that he made the other mice kiss before they conferred with him about various happenings around the apartment. I'm pretty sure he was in it for the long haul.


You kill one fucker, twenty show up to its funeral.


That would be very dangerous and possibly the plot of some hard sci-fi thriller. If immortal mice were to somehow escape the lab and breed in the wild we could rapidly end up with massive populations of mice that never die of aging, ultimately collapsing entire ecosystems and food chains, leading to the end of humanity.


1. Of course they should be sterilized.

2. The most common causes of death for wild mice are predation, diseases, and starvation. Theoretically immortal mice have no chance in the real world if not very well-adapted to these conditions.


It’s also not hard to imagine that an immortal organism has higher metabolic needs. Meaning they are more prone to starvation and potentially less fit.


Mice? No, too many predators. Now, crows that would be a different matter. Already seen in the movie "Birds" ;)


It's my understanding that mice don't live long, because slower aging didn't provide a significant evolutionary advantage (lot's of predators, mainly). Instead the rate of reproduction settled at a very high level [1]. So by that logic, engineered, non-aging mice wouldn't have much of an advantage in the wild.

[1] https://biologyinsights.com/the-mice-mating-process-and-thei...

Fascinating, really.


even focusing on age-related death, you assume that such treatment is one-and-done deal instead of continuous pharmaceutical life support


So they won't be immortal for too long.


active support do be like that


Well there is _Mrs. Frisby and the Rats of N.I.M.H._....


Immortal is not invincible.


Time for a The Secret of NIMH rewatch.


Someone explain to me why this is on the front page.


I don't know, "random" wikipedia articles often pop up on the front-page.

It's been speculated that some groups use random wikipedia articles to test-run their botting. I think a more charitable explanation is often that it's something or relates to something that's going viral on other media, and we get to experience the wash of that, turning up here.

The HN ranking is also very enigmatic. You sometimes get articles whose presence you can't fathom, but by the time you refresh it's disappeared entirely. It feels like the live front-page is built for reactivity, not for stability.

That's perhaps for the best given there's no "recent trending" type page for that.

Edit: This one was submitted 2 days ago, and randomly got front-paged today. It shows "2 hours ago" but mousing over shows the original meta-data of 2 days ago, so this returned via the second chance pool.

Genuinely worthy or a fat-finger I wonder?


I vote up "random" articles if I've found them interesting and learned something new. Occasionally I'll post an article and I've had some great discussions over random things. After all, according to the guidelines:

> On-Topic: Anything that good hackers would find interesting. That includes more than hacking and startups. If you had to reduce it to a sentence, the answer might be: anything that gratifies one's intellectual curiosity.


I think it's cool and weird that there is a hybrid celery/lettuce cultivar out there. I would never have found this otherwise.

While I love a wikipedia spelunk as much as the next person, hitting the random button rarely gets you truly interesting articles. You're more likely to get a random soccer player or an unremarkable neighborhood in India. None of which would end up on the front page.


Another way to detect the odd way HN handles articles it re-pushes to the front-page, the wikipedia submissions page, and the submitter submissions page show the original 2 days ago submission time:

https://news.ycombinator.com/from?site=wikipedia.org

and

https://news.ycombinator.com/submitted?id=bookofjoe


Because people clicked the upvote button. It means people thought it was interesting.

I see these sorts of comments all the time and I have to say that I don't find they add much to the conversation.


> I see these sorts of comments all the time and I have to say that I don't find they add much to the conversation.

I think it's a valid question—sometimes things end up on the front page just because. And sometimes there's an actual reason that not everyone is aware of—maybe it was mentioned in a popular article, or in a movie, or a viral tweet, or whatever. And in those cases, someone will respond with "here's why people are interested in this right now."

Asking "why is this on the front page" doesn't always mean "this doesn't belong on the front page", it can mean "is there some context here I'm unaware of?"


That's fair. Although the replies to this comment I've read seem to have read it the same way as I have.


I won’t say the original poster meant in the sense that I’m talking. Just that, regardless of how it is meant, I often find it a question that gathers useful answers.


Wondering the same thing. It's a pretty standard, mundane household vegetable you can buy at most Asian supermarkets.


It’s new to me!


I clicked because from the name I thought it would be some new genetically engineered form of lettuce, one with perhaps the capability of destroying our ecosystem as we know it. I am now upvoting because it is funny.


Never heard of it and found it to be an interesting read


Exciting! Particularly the emphasis on smoother MCP integrations.

Will be adding the Add to cursor button to Glama later today today.

https://glama.ai/mcp/servers

If anyone from Cursor is reading this, we are rolling out MCP server usage analytics where we aggregate (anonymous) usage data across several providers. Would be amazing to include Cursor (reach me at frank@glama.ai). The data will be used to help the community discover the most used (and therefore useful) clients and servers.


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