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GLP-1 drugs carry a small risk of gastroparesis, which can be severe in some patients. I wouldn't recommend avoiding using them due to that risk if medically indicated but patients should be aware.

https://www.centraloregondaily.com/news/consumer/glp-1-weigh...


Diabetes can cause gastroparesis too. I assume a large number of folks taking these drugs are diabetic.

The physical data centers including power, cooling, and fiber connectivity will be needed. Demand for compute capacity in some form is effectively infinite. But the current generation of CPUs / GPUs / TPUs inside those data center racks might turn out to be worthless if another disruptive innovation comes along.

That reminds me of "Chinese marketing" strategy by a lot of Western companies 30 years ago when their economy first opened up. There are billion people in China so if we can capture just 1% market share there then we'll make a fortune, right? Spoiler alert: it (mostly) didn't work.

Sometimes it works. Steve Jobs aimed for 1% market share with the iPhone:

https://youtu.be/VQKMoT-6XSg?t=4605

Now it is at 20%.


Despite the hype cycle around humanoid robots it's unlikely that they'll advance enough to be capable of replacing many human workers in nursing homes and assisted-living facilities within our lifetimes. Expect to see lots of really sad stories about elder abuse and neglect because as a society we simply won't have the resources to adequately care for them all.

I kinda expect nursing and people paid to give attention to the elderly to be the last job standing. very hard to replace or automate

Paid by whom? That's the problem. The people with money won't be willing to pay more taxes to fund workers to care for a growing indigent elderly population. It's already causing shortages today and will only get worse.

Increasing health span would be a big step forward. More specifically old age dementia.

They don’t have to. If say robotaxis become widespread, you’ve freed up some portion of the labor market to do something else. They don’t have to automate all jobs, just some.

The evidence has shown that this thinking is flawed - disruption of jobs in an industry causes a slow, wrenching, scarring adjustment process that increases the load on welfare programs and makes quality of life broadly worse: https://www.npr.org/2025/02/11/g-s1-47352/why-economists-got...

sure but after 3-5 generations it works out, like with farming and weaving. just gotta wait longer!

If only this was a game of Victoria 3

Look to history. Here's a list of "Fortune 7" companies from about 50 years ago.

IBM

AT&T

Exxon

General Motors

General Electric

Eastman Kodak

Sears, Roebuck & Co.

Some of them died. Others are still around but no longer in the top 7. Why is that? Eventually every high-growth company misses a disruptive innovation or makes a key strategic error.


As Goodhart's law states, "When a measure becomes a target, it ceases to be a good measure". From an organizational management perspective, one way to partially work around that problem is by simply adding more measures thus making it harder for a bad actor to game the system. The Balanced Scorecard system is one approach to that.

https://balancedscorecard.org/


This extends beyond AI agents. I'm seeing it in real time at work — we're rolling out AI tools across a biofuel brokerage and the first thing people ask is "what KPIs should we optimize with this?"

The uncomfortable answer is that the most valuable use cases resist single-metric optimization. The best results come from people who use AI as a thinking partner with judgment, not as an execution engine pointed at a number.

Goodhart's Law + AI agents is basically automating the failure mode at machine speed.


Agreed, Goodhart’s Law captures the failure mode well intentioned KPIs and OKRs may miss, let alone agentic automation

Illegal? Seriously? What specific crimes did they commit?

Frankly I don't believe you. I think you're exaggerating. Let's see the logs. Put up or shut up.


Fraud is a real thing. Lying or misrepresenting information on financial applications is illegal in most jurisdictions the world over. I have no trouble believing that a sub-agent of enough specificity would attempt to commit fraud in the pursuit of it's instructions.

Do you believe allegations of criminal behavior based on zero reliable evidence? I hope you never end up on a jury.

Nothing particularly special. Their proprietary technology gives you some minor improvements in performance, reliability, and power efficiency relative to what you could assemble into a rack yourself. But more importantly for large enterprise customers they give you a single throat to choke: if something doesn't work then you can call them up to fix it with some assurance that it will get handled quickly. They won't point fingers at another vendor.

Ferrari will sell all that they make. If you want to purchase one of the highly desirable low-volume models you can't just walk into a dealership and write a check. You first have to purchase a few of the high-volume models to earn enough "points" on their internal customer priority list. A lot of rich guys will buy a Luce just for that purpose, and then leave it in their garage or maybe drive it to the country club occasionally.

For the type of buyer you describe this vehicle parked in the garage, to speculate, may be capable of doing double duty as an automated battery backup for the estate nearby to store energy during times of excess grid capacity and to discharge during periods of high demand or grid interuptions. I would be interested to know if the vehicle includes this capability, or if it could be easily modified to offer this capability. Probably is preferable to an onsite diesel generator for example even if it is not an exactly comparable situation, just due to lower local emissions.

You've got to be kidding. The people who can afford multiple luxury cars aren't going to mess around using them as backup batteries just to save a few bucks on generators for their mansions.

I never understood this concern about the death of literary criticism. So what. Regular books (not textbooks) are so cheap now that for most middle-class consumers if we accidentally buy a crappy one it's no great loss. And if we want to discuss it with others there are plenty of book clubs and online forums for that. We don't need some anointed critic to tell us what to think.

It is just part of the culture of “extreme gatekeeping” that U.S. culture industry.

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