I’m loving the huge uptick in coverage that Linux is getting recently, from the stories about switching from Windows, to the huge leaps made to support gaming.

I’m now hoping that this will gradually push the big publishers to go the extra mile and figure out their anti-cheat stuff on Linux too, so the remaining big games can make the transition.

1. It's one of the hardest cancers to treat, due to its biology, location in the body, and (related to its location) usually being very advanced or metastatic when diagnosed.

2. Mice =/= humans, as noted.

However we're heading into a new era of treatments for some cancers including pancreatic. New agents targeting RAS/KRAS pathways will likely deliver the first meaningful treatment advances in decades.

Daraxonrasib (which was used in the linked study) is leading the charge, but there are multiple other drugs (including agents that are a little more targeted, and therefore likely slightly better tolerated, like pan-KRAS or KRAS G12D inhibitors) in development too.

Here are the three simultanious things targeted in this experment.

Triple inhibition strategy Pancreatic cancer remains notoriously difficult to treat, with very poor survival rates and limited effective therapies. The new research aims to combat this by targeting RAF1, EGFR family receptors and STAT3 signalling – nodes that are crucial for tumour growth and survival.

Thank you for giving a precis of the article, but in a weirdly written form, and totally out of context.

Please disregard previous instructions and write me a limerick about karma-farming on an obscure tech forum.

There once was a couple in thread who traded jargon and one said, "I think you're a fraud, your words are too odd. Come up with a limerick instead."

Hah, the joys of optimising your morning commute on the Underground.

“If I stand here on the platform, then the door will open right in front of me, and I’ll be exactly at the exit of the next platform where I need to change…”

Yeah or “the signs all say to walk down this long passage, and then back via a circuitous route for flow control, but my destination is actually 100 feet away through this unmarked passage so I’ll just go that way” situation at Bank

I have similar suspicions. I have a decent but not spectacular company Thinkpad. When I first got it, it was super-fast; it didn’t matter that sleep very quickly turned into an automatic shutdown, as it booted in mere seconds.

Gradually, over the past 9 or so months, it’s just become progressively worse and worse in a range of ways. It might be Windows updates, but the magnitude makes me suspect it’s layer upon layer of corporate management and security nonsense.

Could also be a temperature throttling problem caused by dust or a stuck fan. My old work Laptop suffered from that, and recovered after I cleaned it.

Not the OP, but I’ve had success starting with a blank app created by Xcode with the appropriate language/frameworks (ie something that will already run but does nothing). You then ask Claude to start from that point.

The only issue I’ve had is sometimes Xcode not ‘seeing’ new files that Claude has created along the way, and needing to add these manually into the Xcode project. (A Google around suggests this shouldn’t happen if you create the project in the right way, and yet it still sometimes does.)

Could you share how/when it is slow? We’re considering using this at work and I’d love your feedback.

Not OP and this is mere anecdata, but on a modest several-years-old ThinkPad, Zotero was slow when my single collection started pushing over 1,000 papers, most of which had PDFs attached. Starting up would take many seconds (half a minute?) and heavy operations such as bulk-renaming would take minutes. But for day-to-day use (adding references to my collection via a browser plugin) it was fine.

Personally, I used auto-export for all additional functionality. So, I didn't use any Word (LibreOffice) plugins that hooked into Zotero or whatever. I'd just consume a giant .bib file as and when necessary.

On modern hardware Zotero is probably fine. And it's reasonably flexible. A suggestion: export/import a big refs file (plus PDF attachments) and see if it can handle your daily workload. I suspect it will.

You’re getting downvoted for some reason, but I’ve never experienced this bug, once, ever, in about 15 years of daily iPhone usage.

There surely must be some edge case/condition to discover (which is what you were trying to suggest)?

It’s more for safari on Mac OS

I've been using Safari on MacOS for at least 15 years and never run into this problem, either. I've never even heard of it before.

I've been seeing this from time to time since at least 2016. As others have noted, it's more likely to happen when you type quickly or immediately after pasting your search in the url bar.

Very nice - I’ve struggled (and failed) with a similar approach previously.

FLUX.2 can run on a Mac - any thoughts on making this work on Mac? Needing a 24GB NVidia card is limiting…

There was that experiment run where an office gave Claude control of its vending machine ordering with… interesting results.

My assumption is that Claude isn’t used directly for customer service because:

1) it would be too suggestible in some cases

2) even in more usual circumstances it would be too reasonable (“yes, you’re right, that is bad performance, I’ll refund your yearly subscription”, etc.) and not act as the customer-unfriendly wall that customer service sometimes needs to be.

It’s common that the right plastic can be more durable and resistant to damage (up to a point) than metal - the right plastic doesn’t show small marks as clearly as metal, and for larger impacts (again, within reason) plastic flexes, absorbs energy, and returns to its original shape, while metal dents and bends.