We use a broad range of technologies:
1. We start with protein engineering to improve the function of the enzymes which make the glowing reaction. We are using a process called directed evolution to achieve this: http://en.wikipedia.org/wiki/Directed_evolution
2. Then we recode the genes coding for our enzymes so that they can be read by plants - here we test a large number of combinations. This uses a whole suite of technologies: Genome Compiler software to design the sequence, DNA synthesis of the parts, DNA assembly using transcriptics and then transient experiments to test the DNA sequence in plants as described here: http://en.wikipedia.org/wiki/Agroinfiltration
3. Finally when we have a DNA sequence which is working well we insert that into the plant germline (so that it's inheritable) using a gene gun:http://en.wikipedia.org/wiki/Gene_gun
How much control does the gene gun process give you over where the new sequence ends up? Is it in the same place in all of your production seeds or do they structurally differ? I guess a related question is if all the seeds come from one ancestor cell where the insertion was done or if you do the insertion multiple times?
(I work with human genetics and am fascinated by the prevalence of structural variation.)
The gene gun inserts randomly. We do a large number of insertions and will then test to see which are the best plants and take those forward to production. All the seeds shipped will however come from a single parent.
It's just like having to systemically lie about or not mention any other part of your life. We all do this about a variety of things every day.
> Do strangers come up to people and ask about their religion, and is the problem that you have to lie?
There are certain situations where it can get awkward. E.g. if a boss or friend asks which church you attend.
I usually just elaborately lie and say I'm religious but "can't find a church I like".
That's actually pretty easy for me, because I grew up in a religious house and understand enough christian theology that I can pick something about any given church and maintain internal consistency in my complaints.
People sometimes think I'm pedantic, but usually don't know much systemic theology or church history, so I can just escalate the discussion to a point where they're unsure of themselves and come out looking a bit pedantic, but at least religious. They get to feel smug about the "emotional depth" of their belief, and I get out of the conversation without having make any dangerous lies (e.g. saying you attend a church you don't... bad idea).
That's way easier for me than the alternative, which usually involves an annoying and endless litany of invitations to the person's church or their friend's churches.
> and it's kind of a social taboo to even bring it up during dinners etc.
It's not formally acceptable to ask in a work setting, but depending on the part of the country, it's often informally acceptable (not talking about church-related things would be kind-of akin to a "no personal conversations at work" rule for much of the south and parts of the midwest).
The problem isn't that everyone doesn't learn it, but that noone learns it.
It wouldn't be a big deal if the elective were available but not taken by everyone. The problem is that in most cases, there isn't a programming class. Period. Ever.
> "why aren't we teaching children how to grow turnips?".
Why wouldn't we want to teach kids the basics of gardening? I was taught in elementary school, as part of our unit on "Biology" in second and third grade.
> Well, a committee of scientists that know better than you think results will be worthwhile and disagree.
The article stressed that green lighting the research was a hugely controversial decision. I'm also pretty certain there are a huge number of scientists who do research on animals are wouldn't be comfortable with this research.
Also, I think the parent was rejecting the deontological framework in which the decision was made, rather than calling into question the resulting calculation by the ethics board. So an appeal to the expertise of the panel doesn't make much sense.
So what if it was controversial? Some decisions are controversial. This one received more discussion, input, and thought than most other plans. Just because it did it doesn't make that decisions wrong or unethical.
Another committee of scientists -- another IRB board -- probably would have not allowed the study.
Therefore, the parent's appeal to the IRB process as the harbinger of ethics is misguided.
If any IRB would deem a study ethical, then there's probably consensus among the scientific community on the cost-benefit tradeoff of the study. If one IRB deemed the study ethical, and if there're probably a lot of other potential IRBs that would not, then appealing to some sort of scientific consensus on the matter is a misnomer.
> I might be completely wrong in generalizing but haven't the schools in US picked up on this trend?
There are lots of reasons, but I think the largest contributing factor is that these teaching staff doesn't exist.
In most high schools, there is no dedicated "programming" or "CS" teacher. Often these courses of off-loaded to a business-y person. In my experience, these were pretty useless and sometimes worse than useless. E.g. in one case this person was a retired math teacher who was tenured but awful, and "computer class" seemed like a low-impact place to put them.
If a Math or Science teacher wanted to teach a programming class and had been around for a few years (and got along with their administrators), they could probably get away with teaching one section a year. Maybe scale up if there's demand and the department isn't under-staffed. But that's fairly rare, because lots of math people don't really "get" CS.
1) I do not believe the school administrators "get" computers beyond knowing how to use things like a web browser, email, MS Office, or education databases for K-12 research projects. They cannot set effective policy and direction because they do not have a clue what it is they need to do.
2) Many (most?) parents do not know or care about what programming entails or do not understand how computer programming might be extremely beneficial for their kid. Without parents pushing for these courses nothing is going to change since groups of vocal parents are the one thing that school administrators generally act for.
3) Finding qualified individuals is going to be tough. People who do not understand programming cannot teach kids to program. People who understand how to program AND are good at teaching are an extremely rare commodity. You can find lots of one or the other, but the ones who can do both are probably already employed doing something more rewarding (personally or economically).
4) We, as a society, need to determine what is important to teach. Is it computer science or is it programming? You can get a lot of mileage out of just teaching programming, but CS is a beautiful thing that fits more in line with a true academic mission - but CS does not imply any programming.
I think what worked in our (India) favor, despite the dearth of good teachers was the fact that Computers was an available subject in the nationwide standardised exams. Most of students who wanted to pursue Engineering loaded up on computers because it was easy (& fun) to score (compared with languages at the very least).
> I fail to see how you could write an algorithm if you don't know how to code.
Algorithms have existed for centuries. Computer programs have meaningfully existed for 100 years, if we're generous. And for a lot of that time, you had to design the entire algorithm correctly before running to code, or else you'd have to wait a day or two and try again (unless you were important).
Even today, if you're designing a truly novel algorithm, you're very likely to spend the bulk of your time not coding, and then coding only at the end as a sort of check to make sure you ideas work out. Of course everyone has different processes and YMMV, but mt general impression is that most people who design significant (read publication worthy) algorithms do the bulk of their work away from the keyboard.
And honestly, having taught high school cs students, the best students have this process: 1) try a niave solution, notice it won't work before they even compile. Maybe finish the program just to confirm their suspicion that it's wrong; 2) go to the white board for a while, and probably talk with their friends about potential solutions and pitfalls; 3) design the algorithm, and then code it up. Usually there's no pseudo-code before they start programming, but they have a pretty clear idea of the general structure of the algorithm; 4) test on inputs that they identified as reasons the niave solution(s) discussed at the board didn't work.
edit: the very worst students are the ones who sit in isolation hacking away at iterative improvements on a fundamentally flawed idea. Usually they're trying to get their for loops sorted out and working correctly so that the program actually gets around to giving them any answer, and don't even get around to noticing their solution is completely and fundamentally broken until the end of class.
Which is to say, from my observation, coding-as-problem-solving is not very effective until after you've thought things through in more general, mathematical terms.
> Even today, if you're designing a truly novel algorithm, you're very likely to spend the bulk of your time not coding, and then coding only at the end as a sort of check to make sure you ideas work out.
If you cannot code, you cannot check that your ideas work out on a computer.
> Which is to say, from my observation, coding-as-problem-solving is not very effective until after you've thought things through in more general, mathematical terms.
I don't see how that relates to my comment, I specifically referred to 'writing' an algorithm, as in implementing the algorithm in code, not devising the algorithm in the first place.
> If you cannot code, you cannot check that your ideas work out on a computer.
Believe it or not, it's possible to write provable correct algorithms without writing a single test case :-)
Of course implementing is a useful sanity check. But it's not the important part -- it's not the skill set we should most emphasize in education.
> as in implementing the algorithm in code, not devising the algorithm in the first place.
Is there a particularly pressing reason to teach students who to translate pseudo-code from Wikipedia into <insert favorite language>? Sounds like a perhaps useful but pretty menial skill to me. Not the sort of core skill you'd organize a curriculum revision around for sure.
My point was that "copy an algorithm into programming language X" isn't something which needs to be taught in the first place, and isn't an economically valuable skill because literally anybody can be taught this skill in a few weeks.
If I had to choose between teaching why an avl balanced binary search tree works and forcing students to implement in a chosen programming language from pseudocode, I would choose the former every time. The intellectual maturity is far more valuable -- and harder to acquire -- than the rote skill.
> My point was that "copy an algorithm into programming language X" isn't something which needs to be taught in the first place, and isn't an economically valuable skill because literally anybody can be taught this skill in a few weeks.
That depends on the language, I doubt you could learn much about programming in a few weeks, it requires lots of practise.
> If I had to choose between teaching why an avl balanced binary search tree works and forcing students to implement in a chosen programming language from pseudocode, I would choose the former every time. The intellectual maturity is far more valuable -- and harder to acquire -- than the rote skill.
You are giving yourself a hard choice, just demonstrate both sides.
From personal experience, I've been looking at bst's recently. While messing around in my code, out of the blue I decided to write the struct for the node like this:
typedef struct avl_node_typed {
avl_node_typed *left, *right;
void *data;
unsigned height, population; /* avl algorithm requires height, not number of nodes */
}avl_node;
I could access the nth node in a tree. I had rediscovered the algorithm of order statistic trees, which can be treated syntactically like an array (this can be applied to all ordered trees, not just avl). During this time I was looking up knowledge on avl trees and coding away on my machine. If I was purely focused on the algorithmic side, I don't think I would have found it.
> I specifically referred to 'writing' an algorithm, as in implementing the algorithm in code, not devising the algorithm in the first place.
That's confusing usage of "write an algorithm". There used to be a distinction between "programming" (creatig program structure; sequence selection iteration and all tha stuff) qnd "coding" (taking those paper notes and translating them into the particular programming language being used).
It's easy to find people who could create an algorithm but who cannot also code. For example, you can create an algorithm, but you know nothing about {insert the name of a language which you know nothing about here}.
> That's confusing usage of "write an algorithm". There used to be a distinction between "programming" (creatig program structure; sequence selection iteration and all tha stuff) qnd "coding" (taking those paper notes and translating them into the particular programming language being used).
Apologies for being vague, I presumed the phrase 'writing an algorithm' was sufficiently precise.
> It's easy to find people who could create an algorithm but who cannot also code.
I rephrase that: It's easy to find people who could create an algorithm but can only target a specific architecture, human grey matter.
> It's easy to find people who could create an algorithm but can only target a specific architecture, human grey matter.
"Programs should be written for people to read, and only incidentally for machines to execute."
The key difference is that if the skill of implementing an algorithm in <insert programming language> code can be learned in a few weeks max. It's a matter of whether you've bothered to learn the skill, not whether you're capable of learning the skill.
Learning the problem solving skills to create new algorithms is not so trivial, and often can't be self-taught.
> Harold Abelson, yeah? I was wondering what an assembly programmer would say to this.
Taking my comment within the wider context of the conversation, and the general conflation of "writing an algorithm" with "copying down into a programming language from existing pseudocode", I like to think most notable computer scientists would agree with the sentiment that we should be prioritizing the teaching of algorithms over the teaching of programming.
edit: Most importantly, no one is claiming that these two are somehow mutually exclusive. Only that the latter should be in service to the former, and not the other way around.
That is, when teaching CS, we should teach concepts, and include instruction on how to implement programs because it's a useful tool for learning CS. "Turtle Geometry" is a fantastic example of this, BTW. The focus is on the concepts, with programming as a tool for understanding them. But -- to the refutation of your core argument -- it's definitely never insinuated in TG that the ideas don't exist independently of the programming. Such an insinuation, that geometry does not exist independently of a programming environment, is as absurd as the notion that algorithms can't be written without a machine.
But anyways, your initial claim was that you need to be able to program in order to write algorithms. Which, aside from your highly non-standard use of the phrase, is just clearly not the case.
Also, of course programming has its own set of hurdles. But there's a difference between writing highly optimized assembly and copying an algorithm into Python.
> Getting someone to put themselves 'in the shoes of a computer', is just as difficult.
In my experience teaching, this isn't the case.
If you can teach the student to think precisely and unambiguously about a single algorithm, the unrelenting logic of the machine is no stumbling block; quite the opposite, actually.
It's far more effective and less degrading than having students fight with the machine and get confused about why it won't "do what they want it to do".
> But -- to the refutation of your core argument -- it's definitely never insinuated in TG that the ideas don't exist independently of the programming. Such an insinuation, that geometry does not exist independently of a programming environment, is as absurd as the notion that algorithms can't be written without a machine.
Was that my core argument? My original comment (as pointed out by the omnipresent DanBC) was poorly phrased, and was rephrased as:
> If you can teach the student to think precisely and unambiguously about a single algorithm, the unrelenting logic of the machine is no stumbling block; quite the opposite, actually.
Of course it isn't a stumbling block, logical thinking is required for both, which would also explain why they are both difficult.
Both of the statements in that link are just tautologies...
You can teach computer science without teaching coding. And you can write algorithms without testing them on a computer.
So the tautology that "you can't code if you can't code" isn't a particularly important pedagogical insight when it comes to teaching CS, since CS != coding.
> Of course it isn't a stumbling block, logical thinking is required for both, which would also explain why they are both difficult.
Right. And I'm saying that, in my experience teaching, it's better to teach CS and then let programming be something that kind of just falls out of that naturally, as opposed to focusing on programming itself.
> Both of the statements in that link are just tautologies...
I do not understand, and there are four statements, not two.
> Right. And I'm saying that, in my experience teaching, it's better to teach CS and then let programming be something that kind of just falls out of that naturally, as opposed to focusing on programming itself.
Where did I say that the focus should purely be on programming?
> Where did I say that the focus should purely be on programming?
If you'd be okay with teaching a CS course without programming, we might be talking past one another.
> I do not understand, and there are four statements, not two.
I'm confused. Maybe you posted the wrong link?
Here are the two comments from the linked post:
> If you cannot code, you cannot check that your ideas work out on a computer.
This is only true when it just reduces to "if you cannot code, you cannot code".
Taken literally, the statement is just blatantly false. You could use a computer to figure out properties of your algorithm or for designing an algorithm without actually implementing and running the algorithm; e.g. for getting closed forms of sums, or for finding/verifying the convergent behavior of a series which the algorithm relies on.
So the statement really is only true if it's a tautology.
> I don't see how that relates to my comment, I specifically referred to 'writing' an algorithm, as in implementing the algorithm in code, not devising the algorithm in the first place.
'writing' an algorithm = implement the algorithm in code
So, substituting into your original statement:
"I fail to see how you could implement the algorithm in code if you don't know how to code."
No, you're just confused. You mentioned the two statements in that link, but you have only described one. The other statement you referred to is from my original comment.
Do you have a point, or are you just being pedantic? That is, is there some essence of your position which I haven't adequately addressed? If so, what is that essence?
FWIW Your original statement is referentially transparent wrt the meaning of 'writing' an algorithm ("I specifically referred..."). You were clarifying what you meant by this phrase. So the substitution of your intended meaning into your original statement is justified; in fact, is the entire purpose of your clarification. Otherwise you're just giving a definition with absolutely no context or purpose.
> That is, is there some essence of your position which I haven't adequately addressed? If so, what is that essence?
That essence is something you and I have in common. I believe this thread sprouted because of how my original comment was interpreted. I think you are the first HN reader to actually give a decent word for word analysis of my comments. A lot of the time I just have to endure obvious misinterpretations, elaborations, misquotes or sometimes just plain fabrications. It's good to come across someone who takes time to read boring old English.
Ok, fine "algorithms" have been around for centuries. There is no disputing that. But without the notion of "programming," you're missing an entire style and class of algorithms.
Generally, algorithms are described in terms of pseudo code using programmatic language as well as terms of set theory or graph theory.
That said, I don't see why it is shocking to people that 12 year olds aren't learning CS in school.
> But without the notion of "programming," you're missing an entire style and class of algorithms.
And if you focus on programming, you miss the forest for the trees.
You can teach CS without teaching programming, and it will still be valuable.
You can teach programming without CS, but the skills you end up teaching will just be skills -- they're non-transferable and aren't going to be useful in 10 years.
> Generally, algorithms are described in terms of pseudo code using programmatic language as well as terms of set theory or graph theory.
I think the latter semantic descriptions are almost always the more important ones.
Certain parts of software engineering research are moving in this direction, psychology as a the primary toolbox for research.
Not sure how I feel about that. As far as science goes, Psychology isn't exactly the epitome of rigor. On the other hand, the problem really boils down to asking hard-to-investigate-scientifically questions, mostly about humans.