Back in August of 2021 I started tracking my headaches. I was experiencing 10+ debilitating migraines a month and had modified a number of variables in effort to reduce them (sleep, stress, water/caffeine intake, etc).
In September I got a blood panel from my GP and noticed low levels of essential vitamins. In October, I had 12 migraines. I started supplements for B12, Vitamin D, Vitamin K, etc. The migraines decreased each month: in November to 9, then 3, then 1. In February I had my first migraine free month in years.
Neurology is complicated. Migraines/headaches can be caused by a variety of factors. I chose to rule out things in my control (diet, exercise, stress, sleep, and finally vitamins) before taking daily use migraine medicine.
I've experienced the vitamin thing too, even when taking a multivitamin. Turns out that I don't absorb vitamins in a pill very well, switching to chewables and chewing the hell out of them has eliminated a ton of weird physical/mental things for me.
You can crush the tablets with a mortar and pestle, which you can buy online. A mortar and pestle is very cheap and is basic lab equipment. Alternatively you can use a pill crusher which is available in pharmacies.
You can buy empty capsules (gelatin/vegan/flavored/etc.) online or at a local vitamin/supplement store. They are in standardized sizes like 0 or 00 or something similar.
You can fill the capsules with the crushed tablet material using something called a “pill machine” (search for it online). The pill machine that you buy needs to match the size of your capsules. So if you buy 0 sized capsules, you need to buy a capsule machine that uses size 0 capsules.
Multivitamins are often sort of a scam: they contain cheap versions of vitamins that are not directly bioavailable, and essential minerals that are in a non-water-soluble form. All this leads to poor bioavailability.
In addition, some vitamin forms are actively harmful, such as the very common vitamin B12 form, cyanocobalamin, which releases cyanide as it becomes bioavailable. Better B12 forms such as methylcobalamin can be demethylated enzymatically and the free cobalamin is then able to bind to free cyanide (or other toxins) and remove them from the body.
Two-Per-Day Capsules from Life Extension, either directly from their site or resold via Amazon. It's everything you should need, in a capsule form which should have no problem coming apart in your stomach. It's around $15 a month.
If you want the ultimate, look at Life Extension Mix, which is 9 big tablets or 14 capsules per day because there's so much stuff in it, but this is overkill for most people (and at something like $50 a month it is not cheap).
Same here. D and B12 were drastically low. Though mine were not migraines really, but close. Occipital nerve pain. Supplements (B12, D) and neck exercises, and heat fomenting have been of tremendous help. Touchwood!
I get really bad migraines when I fast sometimes, a random youtube video I came across suggested it might be from a mineral deficiency and suggested taking some Himalayan salt and to my surprise it works really well for me, knocks out my migraine within an hour every time.
Not to take away from your great efforts to solve this problem but you controlled for a few key variables in your experiment but not for the placebo effect which is one of the most important factors to rule out in such experiments.
Good question. Indeed, I prioritized improving my vitamin levels for health reasons, including the possibility that it may reduce my headaches, rather than running a purely scientific experiment. If the migraines come back while I maintain normal vitamin levels, I'll continue my experimentation!
What I meant is that you can't say with absolute confidence that supplementing for vitamins cured his migraine without accounting for the placebo effect in that experiment.
It's not a valid experiment regardless. There are too many confounding factors and too small a group.
It doesn't matter. Medicine is a lot less about proper science than we'd like to believe. It's about helping people feel better. Science is a crucial tool for that, but it doesn't always work, while random guessing sometimes does. Even the science is often supplemented with random guessing.
Eventually, you take enough random-guesses-that-worked and apply science to it. That gives you a lot more confidence to recommend it to other people. But often, confidence is all you get, rarely certainty.
Yeah, you're definitely right; I should have added in the end "among many other factors".
While I admit that n is pretty small indeed and thus doesn't qualify for a proper and rigorous clinical experiment, the reason I mentioned the placebo effect in particular is because of the fact that some symptoms or diseases have some psychosomatic streak to them, if you will, and therefore the role of the placebo effect in these cases becomes more pronounced to research and investigate but if the OP felt way better after the treatment, that's what it all counts like you said.
It was no nitpicking or mischief on my part raising this issue :)
Well said. We do so much damage to our own bodies and environments. This compound each other in unknown ways. But it is hard and takes specific effort to correct.
I'm working on the next version of JS8Call[1], a digital mode for amateur radio, that enhances the mode by using some of the latest RF research (LTE/5GNR/Turbo Codes/Polar Coding) for sending reliable messages over weak signals/links.
You will not usually have nor do you need line of sight for HF radio. The radio waves are reflected by the ionosphere at various angles and heights, allowing the signal to be received at many different distances at once. Radio waves at the correct frequency hit the ionosphere like stones skipping along the surface of water.
Thanks for your work. JS8Call seems really cool, but I can never make any contacts with it. Maybe bad luck, but every time I try on 20m through 80m there's nobody on the other end. (FT8 and friends working fine.)
Hey Jordan, fancy running into you here! W7RLF here, miscdotgeek.com. We've talked before on FB and groups.io. I must say, if it weren't for JS8 I'd be off the air right now. Soooo much life stuff going on.
This looks like an interesting finding. Unfortunately, the trade-off for this type of efficient small data storage is real:
> Note that LSM-trie uses hash functions to organize its data and accordingly does not support range search.
Range search, while not directly applicable to all data sets, is an important feature of the LSM data stores compared (LevelDB & RocksDB).
The authors acknowledge this and say:
> There are techniques available to support the command by
maintaining an index above these hash-based stores
So, don't plan on using an LSM-Trie for a direct replacement for your LevelDB or other LSM-Tree based projects that rely on Range searches without considering the additional complexity of building and maintaining an index to perform those Range searches.
For the use-case that the paper presents, I don't think that range search is that important. Most use-cases for LSM-trees so far have been keeping in-memory metadata costs down (i.e. replacing storage engines such as Bitcask), and converting random writes into sequential writes so as to make the most of disk throughput and not wear out SSDs. LSM-trees have had shortcomings in the past with write amplification, and I think this paper does well in addressing that (besides pushing the envelope in terms of reducing in-memory metadata costs).
Would be good to start off your landing page with a headline and some copy explaining your product. I didn't quite get it at first.
You need something like...
Lanes is a simple to-do list with a built in pomodoro tracker designed
to help you stay focused during your day.
-- Insert screenshot of Lanes in action --
Here's how it works:
1. Build your to-do list for each day
2. When you're ready to work, start a pomodoro tracker.
The top task for the day is what you should be working on.
3. Once your pomodoro is up... stand up, stretch, and if you've completed
your task, mark it as done.
4. After your short pomodoro break, goto 2.
-- Insert testimonials about how lanes helped your customers save X
amount of time or get N things done or achieve 100% increase
in tasks completed --
What are you waiting for... you should sign up
for Lanes and start getting things done!"
The issue is, I went to the "What is Lanes" page, clicked on each of the features to see a description and got...nothing of value. The feature became bolded and crossed-out, and that's it. No video loaded, no text appeared.
...seems like pretty basic advice, but I find it very helpful - thanks for making this comment; my own project, zejoop dot com would benefit from a landing page makeover along these lines. I have struggled with this (a clear landing page and CTA) so, a straightforward, easy-to-implement formula helps. Thanks!
Thanks for looking, and I agree with your assessment. I'm no designer, and only a novice developer. I have a friend who is helping me address weaknesses by designing UI/UX for eventual package as iOs app. I checked your guide; that may be helpful as well. Your feedback /help is appreciated. Will fix.
Yep. They are MS ingenieers, of course Windows is easier for them. Plus it's good publicity. Given that they are paying for it, it's fair they start like that.
Exactly, we started on Windows out of ease-of-start/momentum. There are absolutely no plans to make this a Windows-exclusive. Basically we want to show this work pans out before working before putting in the work to make it cross-platform (we have an open issue to move to CMake to help solve the cross-platform problem: https://github.com/Microsoft/Pyjion/issues/76).
It's exploratory in the sense that we are seeing if this general approach works for CPython. But if this exploratory work shows promise, then we will see it through. And since I'm also a member of the Python development team I always want to see Python be faster and succeed more. :)
Pyston seems to be catching up to PyPy fairly quickly ...not sure if there is anything transferable to pyjion, but if you haven't done so might be worth checking out.
Also for getting around the GIL, PyParallel seems to have a really interesting (and seemingly successful approach: http://pyparallel.org/
Its being worked on by one of the Guy's at continuum...and It's definitely in continuum's best interest to help python's future so I'm sure they wouldn't mind collab.
Trent already replied about PyParallels (and yes, we are aware of his work).
We are also aware of Pyston. There might be a chance that they could end up using our JIT hooks, but they also started a full year before us so they are not currently structured to plug into CPython like we're trying to through the API we're designing (although hopefully they will be able to, but who knows).
PyParallel and something like Pydjion are definitely complementary technologies; PyParallel focuses on exploiting things like async I/O and simultaneous multithreading, ensuring that the most optimal technique is being used to go from hardware to OS to Python.
Once we're back into Python, though, Pyjion's JIT'd version of whatever would kick in and do its thing. Perfect combo.
In September I got a blood panel from my GP and noticed low levels of essential vitamins. In October, I had 12 migraines. I started supplements for B12, Vitamin D, Vitamin K, etc. The migraines decreased each month: in November to 9, then 3, then 1. In February I had my first migraine free month in years.
Neurology is complicated. Migraines/headaches can be caused by a variety of factors. I chose to rule out things in my control (diet, exercise, stress, sleep, and finally vitamins) before taking daily use migraine medicine.