There's two SSRI-like drugs called vilazodone and vortioxetine that are indicated for it, as is esketamine.
There are also a few antipsychotic-like drugs that are used at low doses for antidepressant effects along with other antidepressants, but I'm not sure if the newer ones are indicated for depression, or if the newer ones are just reformulations of existing medications. It looks like there's a newer olanzapine combination on the market.
AdQuick | Senior Software Engineer, Full-time | Venice, CA | Onsite or Remote | https://www.adquick.com
AdQuick is building the AirBnb for Outdoor Advertising. Our mission is to make outdoor ads easy to buy and measure (think billboards, posters, transit ads, etc.).
We are a Series A-stage startup with 30 people and a product team of 15. The founding team consists of startup veterans who were early at Instacart. We are funded by Garry Tan & Alexis Ohanian's VC firm, Initialized.
Our engineering team has been remote/distributed since well before Covid, so remote is in our DNA.
We have big problems to solve:
* Getting the entire supply-side on our platform (we're 20% of the way there)
* Getting the entire market demand on our platform (we're making significant headway)
* Making outdoor advertising measurable (we're using interesting data science models to do this)
* Making outdoor advertising INSTANT like AdWords/FB Ads
Our tech stack:
* Ruby
* Rails
* Postgres
* Heroku
* React
* Kotlin & Kafka for high-throughput systems
* Stimulus JS / Stimulus Reflex
We're looking for:
- Experience in our stack or similar technologies
- 3+ years experience in working on production systems
- Folks who explicitly want to be at a startup – you take a lot of ownership and care deeply about building great products
Shoot me an email at vic [at] adquick [dot] com if this sounds interesting to you!
Shouldn't "Show HN" rules also apply to "Launch HN"?
"Off topic: ... sign-up pages, newsletters, lists, and other reading material. Those can't be tried out, so can't be Show HNs. Make a regular submission instead."
(I'm going to mark this subthread off topic to be fair to the founders, who haven't broken any rules.)
It's a good question that has been on my mind too. I'm going to revisit the Launch HN process once the W21 stampede settles down.
You guys have probably noticed that we've been stacking two Launch HNs per day for a while now. This is because of how big the W21 batch is. Demand for Launch HNs is growing as YC grows; meanwhile frontpage supply is strictly limited. Not sure yet what to do, but the 'price' is going to have to go up somehow!
This subthread was at the top of the page. When a comment like this appears, it means that many other readers have the same question, and if it's upvoted to the top of the thread, that's even clearer.
They follow one set of YC advice, but not another set of YC rules (what hpvic03 wrote). Although I do think YCnews takes Launch HN and Show HN differently. The first is only available to YC companies while Show HN is for anyone.
> Besides, tons of apps and services launch via [insert shitty "growth hacking" launch strategies]
Yeah, tons of them do but let's avoid that here if we're trying to keep the level a bit higher than just fad-of-the-day applications.
Personally, I enjoy React on the front-end but don't currently like any back-end framework, so Reflux may well be better in aggregate.
(FWIW, I have a PhD in computer science and big part of that was on web applications and frameworks for them, combined with ~15 years commercial experience mastering web development, so this wasn't meant to be a middle-brow dismissal. As I said, it is exciting, I'm just not convinced.
I think there is some merit in the argument that too much cleverness can be dangerous. Battle-hardened is tricky; I agree TodoMVC is meant to be a minimalist demo, but if a minimal demo can have subtle bugs caused by the cleverness of the data binding, how much more so a real app with a much more complex data model?
But I guess it does eliminate whole other classes of bug, so I can believe it works less buggy and more productive better than React+some back end.
I certainly find the current front/back split endlessly painful. I am also excited by the new React Server Components which might be another good solution to that.)
EDIT TO ADD: I guess what I was trying to say is: I found this interesting, and I looked at it, and then I found this bug in the example, and I wonder if this framework might make a bug like that more likely because the power of making some things easier is obscuring what is happening in some cases, and I don't know if that trade-off is worth it.
I love hearing this story! I'm not in the job market since I love where I work at the moment (though don't love our tech stack) but I'm really hoping to find something, preferably using LiveView, for my next move. It's really nice to hear about companies having success with this kind of tech! It's the first tech I've been really excited about since learning Rails eight years ago (which was far too late!)
I have had co-founders on businesses and none of them ever worked out. It might just be me, but I have a hard time being motivated to really go through the hard stuff if I think someone else is a backstop or will do it for me.
My business that I started and built entirely alone is by far and away the most successful one and has made me a multimillionaire.
Whenever anyone asks me, I always recommend people to start a business on their own and just grind it out.
