The paper offers an interesting signal that heavy gabapentin prescribing tracks with higher dementia/MCI diagnoses, especially in 35-64-year-olds. Yet substantial unmeasured confounding, possible reverse causality, and modest absolute risk increments mean we’re far from proving gabapentin is neurotoxic. It’s a reminder to prescribe purposefully, review regularly, and keep cognition on the monitoring checklist—but not a reason for abrupt discontinuation in patients who benefit.
I was going to post this exact same comment. I was obsessed with Etherpad when it came out and to this day, reminisce about it whenever I fire up a Google Doc. Can’t wait to try this.
Non-removable storage isn't the problem. You have identified one actual problem: privacy. But even this isn't a real problem if you turn on system-level drive encryption:
Soldered-in components make for higher quality, lower cost production. Anecdotally, every Windows machine I've had has failed. Every MacBook machine I have replaced after 4-5 years when I wanted to upgrade to the latest technology.
What does restore mean this context? I’ve downloaded files from their online portal without providing a key. Perhaps restoring in this context means having them mail you a hard drive.
It’s a false narrative that this was about politics and non-work things in the workplace. It was a workplace issue that blew up and employees were annoyed with how the founders handled it.
No, it's pretty fucking stupid all the way around... I broke my own rule and went to that garbage news site The Verge and read Casey Newton's article.
A list of names that sound or look funny.
Wow.
The amount of disdain I have for idiotic busybodies who would fuss and fret over such a thing cannot be overstated, or even quantified.
How about just ignoring the list? How about saying to someone, when they tell you about the list, "That's dumb. Grow up, <name>."
How about just going on about your day.
The fact that any human being would think a list of funny names should be a fireable offense is a testament to this new idiotic religion of Wokeness. A bunch of shitty people traded Christianity for another religion where they can be insufferable assholes, under the guise of righteousness.
>Do you think that kind of aggressive tone would be suitable in a work place?
No it wouldn't be, but this isn't work, it's an internet comment section. You're literally providing his point that "there's a time and a place" for shit like this, and work isn't one of them.
My comment was a reflection on the topic. Its interesting how one person is offended someone else taking offense to social issues but somehow sees their own outrage as justified.
> A third of Basecamp’s workers resign after a ban on talking politics. (NY Times)
Great PR recovery after, from what I can see is one of the worst management foul-ups I can remember. But then PR is one thing that JF and DHH are good at.
If telling people to "get over it" about a list of names and then they don't want to "get over it" and then telling them to go pound sand is the worst management fuck-up you've ever seen, then you need to never - and I mean never - quit your current job, because its pretty clear your management team is unbelievably competent.
In fact, send me a link to your company's Careers page, because I want to work for a company that's got their shit together so thoroughly.
Losing a third of your staff in one day over something that started off as a list of customer names counts as astoundingly bad management by any measure.
Don't start saying it was all due to the people who left - there were a number highly respected, long standing and apparently extremely hard working employees in that list. And they are probably prevented from giving their views due to severance terms whilst DHH in particular will no doubt be blogging about it again within days.
> The hash rate is currently about six exahashes per seconds. Considering the most efficient ASIC miner with a hash rate of about 13,000 GHS (using the SHA-256 algorithm) being sold for about $2,100, an attacker will require about 500,000 hardware units and this will amount to about $1,005,000,000. When we factor in the cost of electricity and cooling daily, this figure rises to $1,006,000,000.
> To successfully conduct a 51 percent attack on the Bitcoin network would cost an incredible $1.4 billion. This massive network supports over 5 million specialized ASIC mining computers, consuming a total of 29 Terawatt hours of electricity a year—as much as the entire country of Morocco. One of the underpinnings of the Bitcoin network is...
The calculations you cite and what the linked page are fundamentally different. The numbers you're citing are roughly what it would cost to buy hardware that would continuously be capable of mounting a 51% attack. The linked site is estimating how much it would cost to rent existing capacity to mount an hour-long 51% attack.
I think the site assumes you already have the hardware, and is just calculating the OpEx of the attack, not the CapEx. Like, if a major mining pool decided to 51% attack a coin.
1. The social benefit. There's research showing that if you have a rich social life and friend network, you live longer. The assumption being that the drink is likely to be with other people.
2. The stress management benefit. It's not healthy to be stressed out. The alcohol's mitigating effect on stress may be greater than the alcohol's poisonous effect, in the right dose, for the right person.
Apple is up 100% because it's kind of the safe haven among tech companies. It actually has the earnings to justify its market value even when using conventional P/E ratio evaluations. This means that if the current oversupply of "fantasy" in the stock markets, especially the tech markets, should ever run out, Apple will most likely be much less affected than most other companies.
Lots of tech-interested investors realized this and decided to take some of the gains made with more risky bets into this "safe haven", because this lets them continue to invest in a tech company at least. And that's why the stock is up regardless of any new groundbreaking product from Apple.
Current valuations, Tesla and Apple among the most prominent, are so far disconnected from reality that it echoes the dot com bubble. But this time, the cause is not dot com mania -- but buybacks, driven by reckless financial policy.
1. VR/AR finally become a thing as the tech becomes small enough, powerful enough, and wireless enough to be a good UX. Facebook's investment in Oculus pays off as Oculus becomes their main profit center, and we transition to a Ready Player One reality.
2. The world faces increasingly alarming & extreme weather disasters. The damage will be utterly devastating and start to really hurt economies. Governments will still be inept at managing these crises. People who have the means will move to lower-risk areas like the Pacific Northwest, driving up real estate prices. Those who are poorer will suffer from homelessness. There will be massive encampments like we've never seen before of displaced families.
3. MDMA and psilocybin will be legalized for medical use and will revolutionize mental health care for depression and PTSD. Which is great because we'll all need a lot of mental health care.
4. Trump loses his re-election bid and ultimately flees the country to avoid consequences as the world closes in on him. He loses his US assets but is given safe passage by a foreign power he has had corrupt dealings with.
5. CRISPR is touted as the tech of the decade as it cures a major disease and appears to have incredible potential. At least one nation violates international ethical standards in their experimentation with CRISPR, igniting a debate over whether we have opened a pandora's box. There are protests and our CRISPR anxiety is evident in pop culture.
6. Americans finally catch on to the bidet/washlet craze thanks to an incredibly effective viral ad campaign.
7. Learning Chinese in school becomes more common because China has become the dominant world superpower. India rises to second, and US falls to third.
8. Bitcoin will cost $500k+ per coin, having peaked at 100-150k by 2022 and 500k+ by 2026. There will be a Silicon Valley-esque tv comedy about rich crypto bros that everyone hate-watches.
9. There will be a major pandemic that scares the shit out of everyone because we are woefully unprepared for it.
10. We're all going to become preppers by the end of the decade because there will be so many potential existential threats.
11. Water will become a lot more expensive, driving major innovation around desalinization.
12. Lab meat will have it's first big success a la the Impossible Burger as clean/lab meat tech becomes commercially available. There will be a thriving DIY culture around growing meat at home.
https://chatgpt.com/share/68709753-d2ec-8010-ba8b-e7b57d610e...
TLDR: