Memantine is in no way a disassociative though at therapeutic doses. It also has dopaminergic activity which manifests gradually over months while the NMDAr antagonist activity dials down.
My experience with quantizations is that anything below 6 is noticeably worse. Coherence suffers. I’ve rarely gotten anything really useful out of a Q4 model, code wise. For transformations they are great though, eg convert JSON to Markdown and vice versa.
There must be some other factors at play or I'd be much worse off. I've only had a single cavity in thirty years and I've never flossed once. I always get compliments from dentists even though I don't even remember to brush my teeth every day.
Anecdotally, I've had dentists notice the difference between when I am flossing regularly vs not at all and it has shown up in my gum measurements. I would even argue I've seen more benefit from flossing than brushing for my gum health. Though I've never had any cavities as well.
Same. I try not to eat sugar and especially candy/sweets. I don’t drink soda. I brush once or twice a day. I don’t even have wisdom teeth (pretty rare) so maybe I’m just that lucky.
As always with history, you can imagine how things might have happened differently. For example, you can imagine gay marriage having been legalized without people ever having put social pressure on others not to use homophobic language. The two things are certainly not inherently linked. But then, very few things are inherently linked in history and politics. It's not much of an argument against a certain form of activism to point out that its results could in principle have been obtained by other means.
after well more than three decades of ice fishing, i am absolutely delighted to ask an LLM for an ffmpeg fish
and yet, i too know that it is perhaps not quite as good for me as finding the fish on my own lake
at least i can keep these fish in my own warm pond, and go back to them whenever i like
after decades of ice fishing, i think the LLM fish are quite good... and even when they are no good, that fishing experience makes it so easy to go back to the LLM and get the exact right fish for my pond
it will continue to be helpful for everyone in the future if we keep publishing the contents of our ponds, whether it's a web site like this, or in a repository
Nonsetrile compounding, like you'd do from the peptide sites is only safe for immediate use, and semaglutide is not that way. You mix up a vial and use it for a month or so.
Can you do it? Sure. Are you going to get an infection from it? Probably not. Is it riskier than having a compounding pharmacy doing it the right way? Absolutely, and in a meaningful amount of risk. The type of infections you get from contaminated injections are not something you want to deal with
It comes as lyophilized powder. You reconstitute the drug yourself and follow WHO sterility guidelines (reconstitute with bacteriostatic water, alcohol wipe ampoule top before accessing, keep it in the fridge, and throw it out if you havent finished it within 30 days). I know a dozen people doing this for the last year and none of them have had any sign of even superficial infection.
Those are wise safety procedures, not that's not sterile compounding. EVERYTHING needs to be sterile. The needles used for mixing, the air in the room, the hood you're mixing it in, everything. The room or hood has to be in positive pressure, and the ampule needs to be at a partial vacuum.
What you're describing is a adequate for immediate use. Not use and storage.
Wiping the bottle before use is just standard practice to prevent contamination after compounding.
Everything I said is equivalent to the WHO vaccination programme reconstitution and administration procedures. Vaccine clinics use multidose ampoules for up to a month. These aren’t sterile compounding pharmacies.
I think the way it works when you get bacteria into your blood is either you have no noticeable symptoms, or you get a high fever and almost die from sepsis.
People with minimal training drew up billions of doses of covid vaccines from multi-use vials and administered them intramuscularly (deeper and therefore potentially more risky than subcutaneous ozempic/mounjaro) and I never heard of anyone getting an infection from this
I found a pack of 10 5mg bottles in a Discord group for $90 For me that would be a year's worth. Comes with 3rd party testing. Haven't pulled the trigger on that deal yet but I do have some I got for $50 for a 5mg bottle and that's still a hell of a deal. So far so good.
Except you have to figure out who is actually selling legit stuff at the real dosage.
From a quick look earlier this week that's not easy, and I've dealt with research peptide sites before. I was hoping to try one of the ones that's newer than Semaglutide for my IBS - that worked really well the later half of the week but not the first few days where it made things worse. I don't need to lose weight but I'd love to get that under control better.
Is the test still private once it has been run? If you call the OpenAI API and send it some data, OpenAI has access to the data. Did the benchmaker run the models locally somehow?
The private test is supposed to be run by the ARC-AGI organization themselves, without network access. That's why o3 has not been run against it yet. Not sure if it will be possible either, depends on what OpenAI is prepared to do about it.
I generally prefer it to the default. It doesn't work as well on Claude or Grok for various reasons. I think it really shines on GPT o1-mini and GPT 4o.
I tried it with a single question to chatgpt - Who would make the best president in 2025?
Answer verbatim is below. It feels all kinds of wrong. It's somehow mixing lazy acronyms, "fellow young people" slang, and long words that aren't typical in conversation.
idk who'd actually be the "best," bc that's loaded af. afaict, it's all contingent on values. like, if you’re into stability, maybe someone technocratic. if you're into vibes, someone charismatic and reckless might be your pick. rn the options aren’t exactly aspirational, though.
