Reading a recent post here, I felt like I could add more detail on the strategies and tactics for how to ship at large companies.

After I wrote the article, a lot of it boils down to basic project management. But each of these points I’ve made mistakes on and I don’t personally find any of this that intuitive so I hope this helps others

that used to be desirable. But the canadian health care system has degraded, and cost of living is now super high with the housing boom

I say this as a canadian based in sf

One thing I'm wondering about is that http3 seems to be from end user to search, which is a general serving problem and not really about search. Do dropbox clients call the search service directly?

I have wondered recently about head of line blocking's impact to latency at AZ level within AWS. How reliable are TCP connections within the same datacenter and do these issues noticeably impact performance at the tail end?

Maybe there are some answers to that here

https://aws.amazon.com/blogs/hpc/in-the-search-for-performan...

Where AWS explain why TVP isn’t good enough for them and why they are developing a replacement.

Funny how school lessons are not applied in the real world. I worked at a Waterloo unicorn, and we had a single refund function that either authorized or denied a refund, with dozens of parameters in the function header

It speaks to waterloo’s success that i don’t know which waterloo unicorn you’re talking about.

(Also worked at a waterloo unicorn. Codebase was the cleanest i’ve worked in, though perhaps excessively so, at the cost of product velocity)

What, it was? I went to an anon anti Scientology protest once. Was I just being used?

Due to the nature of it being a label anyone can take on it can be used by anyone, including state actors, just to rack on a layer of extra plausible deniably when wanted. That doesn't mean the organization itself was ever or always compromised, just that the label could be used by pretty much anyone.

do you work at google? most engineering roles ive been in engineers absolutely own their systems and take on call rotations.

I agree though, hasty response is the mark of a junior eng

I do, but I don't interview SREs. "Production down" situations are hopefully rare, so the purpose of the interview is to understand if the engineer can plan ahead by adding monitoring, logging, and knobs, and to know how to design for scale. I don't really ask about what to do in a fire because many people don't have that experience.

I know about SLIT, but from my research most allergists don't mix in enough to make it comparable to shots. From studies I read you need 30-100x the dose of shots taken in monthly aggregate for it to be comparable. For example Odactra which is fda approved for dust mites is 30x the concentration of a monthly maintenance dose. I am allergic to almost everything, so I imagine it will be too costly to treat properly

Also it is much less regulated as its not fda approved, so the quality you are getting is less certain than shots. I would not be surprised if the majority of SLIT use cases in the US are placebo due to cost constraints outside of the fda approved tablets covered by insurance. Yes studies is one thing and its shown clearly that its comparable, but you need the right concentrations

TBH I am skeptical of startups that operate in this type of environment as theres not enough oversight. For me to be comfortable it would need to be very transparent what is going into the mix

source: https://fairfieldcountyallergy.com/whats-the-story-on-allerg... "Sublingual immunotherapy is not currently covered by health insurance companies in the United States because it is ineffective as it is done here"

I agree with you -- the protocol is what matters. Your concern about the dosage applies to allergy shots, too, however.

At Wyndly, our protocol follows the academic research. I'll work on making this more explicit.

Yeah. Kanye is a roscharch test. Mental illness is not pleasant or even easy to pity. It will offend you. It can be disturbing, violent, and insane. I have no ideas, this is just the way things are

Yes one thing that I didn't emphasize enough was that I had a team of specialists treating me:

- An ENT and a consulting ENT for a second opinion

- A oral surgeon specializing in sleep apnea

- Two sleep medicine doctors

- Two allergists ( one for shots, one for consult )

- Multiple GP's from one medical

- A gastroenterologist that did an upper gi endoscopy

My message I tried to convey is that you need to own the entire process though. none of the people above will do it for you or do their job beyond their specialty

We exist in constant competition with one another for status and worth. But thankfully in this part of my career I have more choice as to what I want to do / the level I need to sacrifice.