Python doesn't do hash table lookups for local variable access. This only applies to globals and attributes of Python classes that don't use __slots__.
The mental cost of multithreading is there regardless because GIL is usually at the wrong granularity for data consistency. That is, it ensures that e.g. adding or deleting a single element to a dict happens atomically, but more often than not, you have a sequence of operations like that which need to be locked. In practice, in any scenario where your data is shared across threads, the only sane thing is to use explicit locks already.
The mental cost of multithreading is there regardless because GIL is usually at the wrong granularity for data consistency. That is, it ensures that e.g. adding or deleting a single element to a dict happens atomically, but more often than not, you have a sequence of operations like that which need to be locked. In practice, in any scenario where your data is shared across threads, the only sane thing is to use explicit locks already.